Etiology of Chronic Renal Failure in Children and Lnfants

Chronic renal failure is an uncommon disease in children with some difference in the etiology in different countries. In this study on 180 children (From 1987 to 1997 in Shiraz) with age range of 3 months to 15 years (mean 8.6±4.2 years). The male to female ratio was 1. 57: 1. The etiology of chronic renal failure in decreasing order of frequency were: reflux nephropathy (25 % ) , glbmerular diseases ( 15 % ) , heredofamilial disorders (15 % ) , urinary stone and nephrocalcinosis ( 12 % ) , pyelonephritis without reflux or other anomalies (9%), vascular disorders (8%), hypoplasia or dysplasia (3 % ) and unknown ( 14 % ) . In 56 % of patients with reflux nephropathy, the cause of reflux was not found (primary). The frequency of disease had a positive correlation with age, ranging from 11.1 % in infancy to 38.4 % in 10 to 15 years. In conclusion reflux nephropathy which can be a preventable disease is the most common, and urinary stone is a relatively common cause of chronic renal failure in this center, which is quite different from reports of most Europian centers.